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Despite lower efficacy and tolerability shown by nasally administered PYY agonists in early studies, long-acting subcutaneous PYY receptor agonists such as PYY 1875 are undergoing early-phase clinical trials to evaluate their safety and effectiveness as monotherapy or in combination with GLP-1 receptor agonists for the treatment of obesity

Obstetrics & Gynecology 2018;132(1)

Notably, weight loss accounted for only up to ~20% of the HOMA2-IR improvement [74]