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* Repeated supratherapeutic ingestion(RSTI) Defined as multiple ingestions during a period greater than 24 hours *

Mechanistically, deeper exploration of the spatiotemporal dynamics of strain-specific metabolic interference and how reprogramming initiates the inflammation-metaplasia-carcinoma cascade is essential, including dissecting crosstalk between mitochondrial stress (Lonp1), epigenetics (GBA1 methylation), and transcriptional regulation of metabolic enzymes

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Further, the amino acid asparagine (Asn) at position eight is replaced with a modified amino acid called Lysine (Lys)