Responses vary widely by the location of the action
Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition
B12 injections are needed when the gut cannot absorb dietary B12 properly, or when oral B12 alone is not enough to correct the deficiency
B12 is a water-soluble vitamin
The driver may be mast-cell-mediated or systemic rather than NF-B-local, and if so, increasing the dose for additional KPV will not address it see the mast-cell note under Phenotype Considerations
Common injection sites include the abdominal area (at least 2 inches from the navel), thighs, or the back of the upper arms