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Although no specific definition is used in the literature for clinically significant WR, it can be defined as progressive weight gain after a successful initial weight loss [1]

Upon ligand binding, GLP-1R activation enhances glucose-dependent insulin secretion, suppresses glucagon release, delays gastric emptying, and reduces appetite, collectively improving glycemic control and promoting clinically meaningful weight reduction [19]

Mechanism of Action Copper-binding tripeptide that activates tissue remodeling genes, promotes collagen and glycosaminoglycan synthesis, stimulates angiogenesis, and modulates metalloproteinase activity to coordinate wound healing and anti-inflammatory responses

Int J Mol Sci (2021) 22(14):7475