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however, metabolically stressed Glp1r cell/ :Gcgr cell/ mice exhibit impaired oral and IP glucose intolerance as compared to HFD-fed controls ( + alpha-cells, and a greater dependency on GLP-1R signaling for insulin secretion, as compared to islets from healthy donors ( + :glucagon + alpha-cells with the onset of diabetes in db/db mice as compared to normal mice (86)

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Of the Firmicutes and Bacteroidetes present in the gut microbiota, Faecalibacterium prausnitzii and Bacteroides thetaiotaomicron along with Clostridium clusters IV and IXa, are among the highest producers of butyrate, a SCFA that without these bacteria would be inaccessible to the host (Roediger 1980

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It is a targeted intervention that directly supports the primary mechanism of this probiotic