IGF-1 LR3 transports glucose out of the bloodstream into muscle cells, potentially causing dangerous drops in blood sugar, especially when injected in a fasted state
Otherwise, they're trying to essentially knock down the quote, unquote, positive outcome
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This preserves the natural pulsatile release pattern and negative feedback mechanisms, typically resulting in a safer side effect profile (Prakash & Bhatt, 2013, Indian Journal of Endocrinology and Metabolism )
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