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Whether it is the 28-day window after a puncture or a 90-day beyond-use date for an unopened vial, these timelines are there to ensure your treatment remains sterile and biologically active

If your plan explicitly excludes these, coverage is unlikely regardless of medical necessity

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The margin for error is razor-thin: MT-1 activates melanocortin receptors (MC1R, MC3R, MC4R, MC5R) at specific concentration thresholds, and overshooting by even 0.2mg can trigger receptor-mediated side effects that derail research protocols entirely

Accessed January 15, 2026 New England Journal of Medicine