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In a trial on tirzepatide, a once-weekly 15 mg dose resulted in a 20.9% reduction in body weight over 72 weeks compared to a weight reduction of 3.1% in the placebo group

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10.1007/978-1-4615-2960-6_149 Chemistry and Biology of Pteridines and Folates Advances in Experimental Medicine and Biology 41 KuglerP.FrhlichD.WendischV

Further studies have reported anti-apoptotic, anti-inflammatory, anti-fibrotic, and mitochondrial protective effects across multiple animal models (Cant et al