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Weight of evidence: Overall evidence is LowModerate : robust mechanistic plausibility and diverse preclinical benefits

Over 68 weeks, those taking semaglutide lost an average of 16.86% of their weight [3]

Once abnormal acylcarnitine profile is detected, treatment focuses on nutrition with carbohydrate-rich (70%) and low-fat ( T(p.Ala214val), indicative of a diagnosis of primary carnitine deficiency

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P.RoskamsT.et al (2012)