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Second, the gut microbiome influences systemic immune balance

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It is driven by iron-dependent phospholipid peroxidation and regulated by several cellular metabolic events, including redox homeostasis, iron handling, mitochondrial activity, and metabolism of amino acids, lipids and sugars [67]

Patients with PFIC may present with a wide variability of signs and symptoms, including cholestasis, jaundice, and pruritus

The HIV transactivator of transcription (TAT) protein has also been shown to further increase oxidative stress and reduce GSH levels