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[9] Clinical trials have consistently demonstrated that gastrointestinal adverse effects are the most frequent side effects associated with tirzepatide therapy

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Soluble fibre (found in oats, beans, lentils, fruits such as apples and pears) and insoluble fibre (present in wholegrain bread, brown rice, vegetables, nuts, and seeds) both contribute to softer, bulkier stools that transit more easily through the colon

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The European Medicines Agency likewise advises against using semaglutide during pregnancy