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Encouragingly, ongoing advancements in anti-tumor drugs and AKR1C3 inhibitors, such as ASP9521 and BAY1128688, are progressing in clinical trials for CRPC treatment (Rizner and Penning, 2020)

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Such disorders are characterized by malfunctions in the nervous system and may occur in otherwise healthy patients after going through an infectious disease [366]

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When NAD+ levels drop, ATP production becomes less efficient