These topics belong in literature interpretation, not product claims
There are several GLP-1 drugs currently marketed including Semaglutide (brand names: Ozempic, Wegovy, Rybelsus), Tirzepatide (Mounjaro, Zepbound), Liraglutide (Victoza, Saxenda), Dulaglutide (Trulicity) and Exenatide (Byetta, Bydureon)
But I think framing how we think about obesity is maybe the place to start
(2) This appears to be due to its modified structure and the fact that the peptide is predominantly thought of as a free peptide

nih Research Applications Within the research setting, Synedica Retatrutide 40mg is used to support studies examining: Multi-receptor agonism and cross-talk between incretin and glucagon signaling pathways Structure-activity relationships in engineered peptide therapeutics Receptor binding assays and dose-response modeling in cell-based systems Comparative pharmacology against single- and dual-receptor agonist compounds Animal model research into energy expenditure and appetite-regulation circuits, where such models are institutionally approved Findings from clinical trial data indicate the compound engages mechanisms involving hepatic glucose secretion, gastrointestinal motility, hepatic lipolysis and fatty acid oxidation, and glucose-dependent insulin secretion mechanisms that continue to be studied to better understand the physiological basis of multi-receptor incretin signaling
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