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Among the tested doses, uridine at 10 mg/mL significantly improved the first polar body (PB1) extrusion rate in aged oocytes without observable toxicity, and was therefore selected as the optimal dose for subsequent experiments
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Similarly, mitochondrial damage plays a key role in the pathological behavior of FLSs, and studies have shown that healthy mitochondrial transfer inhibits LPS-induced FLS proliferation and migration and promotes apoptosis, which can reduce the inflammatory response (80)
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Specifically, glucagon-like peptide 1 receptor agonists (arGLP-1), such as semaglutide, have demonstrated a mean weight loss approaching the 15% threshold [18,19,20]
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