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Formulation and physical evaluation of microemulsion and W/O/W multiple emulsions dosage forms with alpha arbutin, lactic acid, and niacinamide as skin-whitening cosmetics

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Dysfunction of System Xc , depletion of GSH, or inhibition of GPX4 activity can lead to the accumulation of iron-dependent lipid peroxides, ultimately initiating ferroptosis ( 2+ levels in the substantia nigra of PD rats, inhibits neuronal ferroptosis, decreases ROS production, downregulates malondialdehyde (MDA) and -synuclein (-Syn) expression, elevates GSH levels, and ameliorates motor deficits

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Kurd, S.K., Smith, N., VanVoorhees, A., Troxel, A.B., Badmaev, V., Seykora, J.T., Gelfand, J.M.: Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: a prospective clinical trial