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Semantic descriptors of must, should, and may generally but not strictly correlate with Grade A (strong), Grade B (intermediate), and Grade C (weak) recommendations, respectively

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*From randomization to last contact with trial site, regardless of treatment discontinuation or rescue intervention

Volumetric Measured by exact liquid amount, not just by listening to clicks. Pharmacokinetics The study of how a drug moves, works, and eventually leaves your body

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