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Of particular relevance to IGF-1 anabolic research are TSC2 (relieving inhibition of mTORC1, driving protein synthesis) and FoxO transcription factors (inhibiting their nuclear translocation, blocking expression of atrogenes like MuRF1 and atrogin-1 that drive muscle protein breakdown)

9ad), but none of these isoforms displayed a dependency in cancer cell line genetic screens (Extended Data Fig

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Exposing sermorelin to room temperature for extended periods or, conversely, freezing it can cause it to break down and lose its effectiveness

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