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BPC-157 has been shown in research settings to influence angiogenic signaling, nitric oxide pathways, and fibroblast activity, while TB-500 has been studied for its role in actin regulation, cell migration, and wound-healing mechanisms

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In vitiligo patients, an increase in pro-inflammatory cytokines typical of innate immunity, IL IL-1, IL-1, IL-6, IL-8, IL-12, IL-15, and TNF-, is observed in both serum and skin.2,3 Damage-associated molecular patterns The Koebner phenomenon is considered an initial trigger for vitiligo