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This model provides a satisfying structural explanation for how mTORC1 integrates GF and nutrient signals in the context of the lysosomal membrane
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As such, further clinical investigation via an individual patients clinical presentation and the results of complementary laboratory tests may be warranted to guide more specific testing
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Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: an open-label, multi-institutional phase I trial
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