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TREM2 is a lipid-sensing receptor that regulates macrophage responses to extracellular lipid accumulation

The liver may break down the nutrient further before it reaches the rest of the body (this is known as the "first-pass effect")

This framework generates testable predictions and potential monitoring endpointsincluding lean mass trajectory, micronutrient status, fat-soluble vitamin surveillance, and exploratory redox-related biomarkersthat can be evaluated in future longitudinal and interventional studies

DeSantis CE, Miller KD, Goding Sauer A, Jemal A, Siegel RL

systemic adverse events are rare in preliminary reports