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According to NICE guidelines (NG69) , diagnosis requires these episodes to occur at least once weekly for three months

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Resveratrol Antioxidant effect: Resveratrol reduces oxidative stress by activating the Nrf2/ARE signaling pathway and promoting the expression of antioxidant enzymes such as SOD and GSH-Px.Anti-inflammatory effect: Resveratrol reduces the expression of inflammatory factors such as IL-6 and TNF- by inhibiting NF-B and AP-1 signaling pathways.Promote cell proliferation and differentiation: Resveratrol promotes the proliferation and differentiation of fibroblasts and osteoblasts, accelerating tissue repair by activating the PI3K/Akt and ERK1/2 signaling pathways