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HRMS was developed in the 1960s with double-focusing mass spectrometers, but today, time-of-flight (TOF) or Orbitrap (OT) mass analyzers are common, mostly as hybrids with triple quadrupoles (QTOF, QOT) or ion traps in front, allowing fragmentation to reproducible MS/MS spectra [61]
Gentile MT, Camerino I, Ciarmiello L, Woodrow P, Muscariello L, De Chiara I, et al
The dual control theory of feeding is based on the homeostatic view of hunger and satiety, together with the consideration of glucose not only as a metabolic fuel, but also as a signalling molecule, and the existence of specialized neurons containing glucose sensors that activate or inhibit feeding when blood glucose levels change
Some patients report less nausea if they inject when their stomach is not completely empty, whilst others prefer to avoid eating close to injection time
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it's an essential part of the scientific method
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