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This 7-10% difference in strength retention translates to meaningfully different training loads, which in turn affects the muscle preservation signal

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However, as only male rats were tested in the aforementioned study, and since PPG neuron activation was recently shown to have divergent effects on food-motivated behavior and palatable food intake in male vs female rats (51), it is also likely that this PPG neuron accommodation disinhibits female behavior more, contributing to the higher prevalence of binge-like behavior in females, a speculation that needs to be tested